DOTmed Home MRI Oncology Ultrasound Molecular Imaging X-Ray Cardiology Health IT Business Affairs
News Home Parts & Service Operating Room CT Women's Health Proton Therapy Endoscopy HTMs Mobile Imaging
SEARCH
Aktueller Standort:
>
> This Story

starstarstarstarstar (1)
Log in oder Register to rate this News Story
Forward Printable StoryPrint Comment

 

MRI Homepage

With an MR sound system the patient experience gets a tune-up With the music of their choosing, patients anxiety is reduced

New imaging system may accelerate drug development for Alzheimer's cryo-MOST provides more detail than MR and PET

MR shows promise for predicting neurological outcomes in cardiac arrest survivors May also help develop therapies

New research finds brain MR study groups don't reflect U.S. population demographics This must change for large, multicenter studies

Bracco Imaging acquires SurgVision Enables development of a real-time fluorescence image-guided surgery platform

What’s new in MR scanners and coils? A review of new innovations arriving on market

Purchasing Insights: The ABCs of buying an MR Facilities must think about their scanning needs of tomorrow when investing today

Siemens gets 7T MR cleared for clinical use in U.S. MAGNETOM Terra offers benefits for neuro and MSK imaging

Contrasting viewpoints on gadolinium Despite evidence of harm, the industry worries about brain retention

MR detects neurological impairments in newborns with CHD before surgery Detects brain impairments even before cardiac surgery

Computational model of the cortical
and subcortical brain structures that
form the basis of the BrainPrint

Can MR detect Alzheimer's before symptoms have even appeared?

by Lauren Dubinsky , Senior Reporter
A team of researchers at Massachusetts General Hospital (MGH) have found a way to spot individuals in the early presymptomatic stages of Alzheimer’s disease with MR. The scans revealed that those with the disease had asymmetrical brain structures in the left and right sides of the brain.

“Compared to the size of a structure, the geometric shape can pick up subtle changes in sub-structures much earlier,” Martin Reuter, lead researcher, told HCB News. “Lateral asymmetries in dementia may have been overlooked for that reason in the past.”

Story Continues Below Advertisement

The (#1 Resource) for Medical Imaging and Peripherals. Call 1-949-273-8000

As a Master Distributor for major brands Barco, Philips, and Sony, we offer custom imaging solutions. With our renowned OEM Solutions and Service/Repair Center, Ampronix is a one-stop shop for HD Medical LCD Displays--Printers--Recorders--4K Cameras



In particular, the asymmetry of the hippocampus and amygdala increases as the disease becomes more severe. The researchers believe the asymmetry of those and a few other structures could be a biomarker for detecting early-stage dementia.

The team developed a computer-aided system called BrainPrint that represents the whole brain based on the shapes, rather than the size or volume, of the structures. An article published in 2015 in the journal, NeuroImage, showed that BrainPrint can be as accurate as a fingerprint in distinguishing individuals.

This new study used BrainPrint to evaluate structural asymmetries in MR images of 700 patients involved in the National Institute of Health-sponsored Alzheimer’s Disease Neuroimaging Initiative (ADNI). The participants received an MR exam at enrollment and then again every six to 12 months, along with cognitive and genetic testing.

The researchers assessed the data from ANDI participants that underwent at least three MR exams. They were then divided into four groups: those diagnosed with probable Alzheimer’s when entering the study, healthy controls with no sign of dementia, those with mild cognitive impairment (MCI) that remained stable over two to three years and those with MCI that progressed to Alzheimer’s.

BrainPrint revealed that differences in the shapes of the hippocampus and amygdala were highest in individuals with dementia and lowest in the healthy controls. Among the group that was diagnosed with MCI, the baseline asymmetry was higher in those that developed Alzheimer’s, and increased even more as symptoms became apparent.

“Clinical Alzheimer’s disease diagnosis occurs very late. By that time decades of advanced neurodegeneration have taken their toll and large portions of the brain are atrophied,” said Reuter. “Recovery at this stage is unlikely, even stopping or significantly slowing the neurodegenerative process at this time will be very difficult.”

If presymptomatic or early-stage individuals at risk of developing the disease are identified, they can be recruited into studies investigating novel therapies, because preventive treatment can still be successful.

Reuter and his team are planning to further explore the relationship between brain asymmetries and established Alzheimer’s disease biomarkers to get a better understanding of the underlying biological mechanisms.

“This approach is a building block for spotting early-stage Alzheimer’s,” he said. ”For high-accuracy Alzheimer’s prediction, genetic markers, other imaging markers, as well as test scores, lifestyle, nutrition, etc., will need to be considered jointly.”

MRI Homepage


You Must Be Logged In To Post A Comment

Werben
Erhöhen Sie Ihren Bekanntheitsgrad
Auktionen + Privatverkäufe
Den besten Preis erzielen
Geräte/Geräteteile kaufen
Den günstigsten Preis finden
Daily News
Die neuesten Nachrichten lesen
Übersicht
Alle DOTmed Benutzer durchsuchen
Ethik auf DOTmed
Unseren Ethik-Standard anzeigen
Gold-Parts Verkäufer-Programm
PH-Anfragen erhalten
Gold Service Dealer-Programm
Anfragen empfangen
Gesundheitsdienstleister
Alle Gesundheitsdienstleister-Tools anzeigen
Jobs/Training
Einen Job suchen
Parts Hunter +EasyPay
Angebote für Geräteteile erhalten
Kürzlich zertifiziert
Kürzlich zertifizierte Benutzer anzeigen
Kürzlich bewertet
Kürzlich zertifizierte Benutzer anzeigen
Rental Central
Geräte billiger mieten
Geräte/Geräteteile verkaufen
Das meiste Geld erhalten
Service-Techniker Forum
Hilfe und Beratung finden
Einfache Angebots-Anfrage
Angebote für Geräte erhalten
Virtuelle Messe
Service für Geräte finden
Access and use of this site is subject to the terms and conditions of our LEGAL NOTICE & PRIVACY NOTICE
Property of and Proprietary to DOTmed.com, Inc. Copyright ©2001-2017 DOTmed.com, Inc.
ALL RIGHTS RESERVED